Ivermectin and Alcohol: is It Safe to Mix Them

Ivermectin for alcohol use disorders

We have carefully reviewed the data published by the NPS, TGA and other reliable sources of information. We didn’t find any mention of a contraindication to Ivermectin with alcohol. There is no mention of ethanol or alcohol in the “Drug interactions” section.

We only found studies on the pharmacokinetic properties of Ivermectin. It turns out that the drug’s bioavailability (the amount of the active substance getting into the blood system) may depend on the presence of alcohol in the gastrointestinal tract.

When taken orally in the form of a water-alcohol solution, Ivermectin bioavailability increases by two times compared with oral tablets.

What does this mean in simple terms?

It means that when taking a standard dose with alcohol, the Ivermectin concentration in blood plasma can be twice as high as when you take the tablet without alcohol.

Based on this, you can conclude that mixing with alcohol affects the therapeutic effect of Ivermectin. Besides, it may cause or aggravate side effects such as:

  • Diarrhea.
  • Drowsiness.
  • Stomach discomfort.
  • Loss of appetite.
  • Nausea.

Is Ivermectin safe with alcohol

There is little information on ethanol’s effect on Ivermectin’s pharmacodynamics. But surely you shouldn’t expect any trouble if you drink beer (one glass).

But you must understand that due to the effects of alcohol on the CNS and the potential for interactions, you shouldn’t take it with most existing prescription and over-the-counter medications.

Ivermectin for alcohol use disorders

Scientists conducted a pilot study and made an exciting conclusion. According to experiments on mice, Ivermectin can cause a decrease in ethanol consumption. Scientists suggested that people with alcoholism may also have this effect, but at the moment, this assumption has no scientific justification.


As you can see, there is not enough information about the effect of alcohol on the therapeutic effect of Ivermectin. Doctors don’t recommend taking this drug with alcohol as it may be associated with some risks.

To avoid any adverse reaction, you should wait until Ivermectin excretes from the body (half-life is 10–14 hours). After that time, you can drink alcohol without fear of negative consequences.